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Fibre architecture of the human hippocampus. Detail of a human brain section showing the architecture of fibres down to single axons in the hippocampus, revealed by 3D Polarized Light Imaging. Colours represent 3D fibre orientations highlighting pathways of individual fibres and tracts.
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A combination of micro and macro methods sheds new light on how different brain regions are connected

To understand how our brain works, there is no getting around investigating how different brain regions are connected with each other by nerve fibres. In the most recent issue of Science, researchers of the Human Brain Project (HBP) review the current state of the field, provide insights on how the brain’s connectome is structured on different spatial scales – from the molecular and cellular to the macro level – and evaluate existing methods and future requirements for understanding the connectome’s complex organisation.

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