A new field of science has been emerging at the intersection of neuroscience and high-performance computing - this is the takeaway from the 2022 BrainComp conference, which took place in Cetraro, Italy from the 19th to the 22nd of September. The meeting, which featured international experts in brain mapping, machine learning, simulation, research infrastructures, neuro-derived hardware, neuroethics and more, strengthened the current collaborations in this emerging field and forged new ones.