MR images showing progressive degeneration of brain tissue in a Parkinson’s disease patient. Image adapted from Pieperhoff et al. 2022 .

New study reveals how the volumes of brain regions change in Parkinson’s disease

Researchers of the Human Brain Project (HBP) found that in Parkinson’s disease the volumes of certain brain regions decrease over time in a specific pattern that is associated with clinical symptoms and largely coincides with the pattern described in Braak’s famous staging theory. The new study published in Cortex provides a detailed description of the structural changes over a long period of time and with an unprecedented spatial detail.